“She talked about doing all these marathons around the globe,” he stated. “She thought, ‘Perhaps I might do that.’ She grew to become so targeted. It was really wonderful.”

Greater than a yr later, in November 2015, Ms. Seman ran her first marathon, in New York.

“It was one thing I wanted I might do,” she advised Runners World. “I simply thought, if this was ever one thing I need to do, I’ve to do it now. I signed up for it, and I used to be like ‘What did I simply do?!’ I used to be freaking out.”

Chicago adopted in 2016, Boston in 2017 and Berlin in 2018.

In 2019, Ms. Seman ran her final two marathons, in Tokyo and London, eight weeks aside. This required her to coach as a lot as she might whereas present process chemotherapy.

Ms. Seman didn’t pause or panic. As an alternative, after Berlin, she started working with Daphne Matalene, 46, a working coach.

“Even if you find yourself tremendous wholesome and tremendous educated it nonetheless takes rather a lot out of you,” stated Ms. Matalene, who has run 5 of the six marathons. “Renee was completely undeterred by that. Her aim was to not win; it was not even to run her quickest.”

Ms. Matalene got here up with a coaching routine that labored round Ms. Seman’s remedy schedule. Ms. Seman would run straightforward miles within the morning after which have chemotherapy remedy within the afternoon. Days later, as soon as she had recovered, she would do a future of 12 to 16 miles.

Many runners who attempt to full the six races are coping with well being points or not too long ago had a well being scare, stated Lorna Campbell, a spokeswoman for the Abbott World Marathon Majors.